hPDE7A HEK293

Product Description
Recombinant HEK293 cell line expressing human PDE7A (phosphodiesterase 7A,
accession number NM_002603).

Format
Each vial contains 1 X 10⁶ cells in 1 ml of 10% DMSO.

Introduction
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP by
hydrolyzing cAMP and cGMP to their inactive 5’ monophosphates. These cyclic
nucleotides play an important role as second messengers in diverse physiological
functions. PDE7 is a cAMP-specific enzyme and two PDE genes (PDE7A and PDE7B)
have been identified. PDE7A is widely expressed in various tissues including skeletal
muscle, T lymphocytes, brain and pancreas. Inhibition of PDE7 activity by its inhibitors
leads to elevated intracellular level of cAMP.

References
Malik, R. et al. (2008) Cloning, stable expression of human phosphodiesterase 7A and
development of an assay for screening of PDE7 selective inhibitors. Appl. Microbiol.
Biotechnol. 77 (5): 1167-1173

Fan Chung, K. (2006) Phosphodiesterase inhibitors in airways disease. Eur. J.
Pharmacol. 533(1-3):110-117