PD1, (PDCD1) Fc fusion

Description:
Human secreted programmed cell death 1
(PD-1)-Fc fusion protein, also known as,
PDCD1, SLEB2, CD279 and HPD-L, GenBank
Accession No. NM_005018, a.a 25-167,
expressed in a HEK293 cell expression
system. MW = 42.6 kDa. This protein runs
at a higher M.W. by SDS-PAGE due to
glycosylation.

Synonyms: PD1, Protein PD-1, HPD-1

Application:
Useful for the study of enzyme kinetics,
screening inhibitors, and selectivity profiling.

Assay Conditions:
PD-1-PD-L1 binding activity, measured
using the using the PD-1:PDL1
[Biotinylated] Inhibitor Screening Assay
Kit, BPS Bioscience, Catalog #72003.

Formulated in: 40 mM Tris-HCl, pH 8.0,
110 mM NaCl, 2.2 mM KCl, and 20%
glycerol

Stability: >6 months at –70°C. Avoid
freeze/thaw cycles.

References:
1. Shinohara, T., et al., Genomics.
1994 Oct;23(3):704-6.
2. James, E.S., et al., Genes Immun.
2005 Aug;6(5):430-7.