Thiazovivin, 1.5mg

Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK). It protects human embryonic stem cells (hESCs) from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction (1).

CAS Number

1226056-71-8

Chemical Formula

C₁₅H₁₃N₅OS

Chemical Name

N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

Molecular Weight

311.36

QC Specifications

MASS Spec

Mouse ESC culture for toxicity

Shipping Information

on blue ice

Storage

-20°C protected from light

Stability

Stable for up to 6 months from date of receipt when stored as directed.

Reference

1. Xu, Y., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. (2010) Proc Natl Acad Sci USA 107: 8129-8134