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White to off-white solid. A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. A resistance gene (aph) which encodes a spectinomycin has been cloned from Legionella pneumophila (disease agent for Legionnaire’s disease) kinase and expressed in E. coli. Potency: ≥500 µg/mg. Soluble in H2O. RTECS WG7400000, CAS 22189-32-8, M.W. 495.4. References: Merck Index 13, 8813.Thompson, P.R., et al. 1998. J. Biol. Chem. 273, 14788.Noah, J., and Wollenzien, P. 1997. Nucleic Acids Symp. Ser. 36, 178.Suter, T.M., et al. 1997. Antimicrob. Agents Chemother. 41, 1385.Thom, G., and Prescott, C.D. 1997. Bioorg. Med. Chem. 5, 1081.
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